Protocol Reference
Animal data only
PE-22-28 protocol
PE-22-28 (spadin analog, TREK-1 blocker). The published work on this compound is animal or cell-culture research. No human dosing schedule exists to cite.
PepGuru Research Team·Reviewed Aug 2026
Common vials
Not stocked by our featured supplier
Half-life
Not established in humans
Route in the literature
Not established
Evidence level
Animal data only
How PE-22-28 works
A shortened analog of spadin, which blocks the TREK-1 potassium channel. Rodent work studies it for rapid antidepressant-like effects and for synaptogenesis.
PE-22-28 dosing — what the literature actually supports
Animal data only. PE-22-28 has been studied in rodents only. There is no human trial, no pharmacokinetic data in humans, and no citable schedule.
We publish a schedule when there is a citable human source and we say so when there is not. Filling this space with a number nobody measured would make the page look more complete and be worth less than nothing to you.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for PE-22-28: Not stocked by our featured supplier.
Open the PE-22-28 calculator → Unit converter
Storage and stability
Dry powder
Cold, dark and dry. Lyophilized peptide is the stable form — keep it that way until you intend to use it.
After reconstitution
Refrigerate at 2–8 °C, protect from light, and plan around a limited window. Do not freeze a reconstituted vial — freeze-thaw damages peptides.
Mixing
Run bacteriostatic water down the inside wall of the vial rather than onto the powder, then swirl. Never shake.
Inspect before use
A clear solution is expected. Cloudiness or particles mean discard, not use.
Full storage guide → · Cloudy solution?
Sourcing PE-22-28
Our featured supplier does not stock this compound, and we are not going to point you at a vendor we have not looked at. Use the COA checklist on whoever you do buy from, and check the batch number on the certificate against the vial you receive.
COA checklist → How we vet suppliers
Sources and further reading
For laboratory research use only. This page documents what the published literature reports about PE-22-28. It is not a recommendation, not a treatment plan, and not medical advice. Compounds referenced are sold strictly as research chemicals and are not for human or veterinary use. Some supplier links are affiliate links and may earn us a commission. This never affects tier placement or review conclusions.
