Cagrilintide + Semaglutide
The dual-pathway weight stack: GLP-1 plus amylin, one weekly pin each.
Why this stack
This pairing copies the pharma playbook: the combined CagriSema asset exists because amylin and GLP-1 suppress appetite through separate pathways, and the combination out-performed either agent alone in phase 2. Semaglutide slows gastric emptying and works the incretin axis; cagrilintide works satiety through the amylin receptor. Both are once weekly, which keeps the schedule simple.
The protocol at a glance
Community-reported maintenance amounts, derived live from each compound's protocol page. Click through for titration phases, reconstitution steps and the evidence grading behind every number.
| Compound | Dose | Frequency | Recon | Units/injection |
|---|---|---|---|---|
| Semaglutide Human trial data |
2.4 mg | Once weekly | 10 mg + 1 mL | 24 units (0.24 mL) |
| Cagrilintide Human trial data |
4.5 mg | Once weekly | 5 mg + 1 mL | 90 units (0.9 mL) |
How it is run
- Both once weekly subcutaneous, same day, in separate draws or as the combined vial.
- Escalate each per its own titration; nausea is the limiting factor and slower is better.
- This is a marathon protocol: 16 to 20+ weeks, ending in a taper rather than a hard stop.
What the components report
Reported upsides
- Semaglutide: Significant weight loss in clinical trials
- Semaglutide: Improved glycaemic control and HbA1c
- Cagrilintide: Amylin analog for appetite regulation
- Cagrilintide: Complements GLP-1 therapy for additive weight loss
Cautions
- Semaglutide: Nausea, vomiting and diarrhoea (common on escalation)
- Semaglutide: Reduced appetite (intended effect)
- Cagrilintide: Nausea at higher doses
- Cagrilintide: Injection site reactions
Pulled from each compound's benefits and side effects section. Individual responses vary. Not medical advice.
Track this stack
The free tracker logs each component on its own schedule, rotates injection sites across the whole stack, and counts down every vial with a reorder heads-up.
Sourcing the stack
Same rule as every protocol page: the batch COA matters more than the price. Summit Research Supply is the supplier we feature; code PEPDOSE applies to each component.
Summit links are affiliate links. Our COA checklist applies the same way to any vendor.
