Semaglutide protocol
Semaglutide (GLP-1 receptor agonist). Dosing on this page comes from a published human trial or an approved product label, cited below.
How Semaglutide works
A GLP-1 receptor agonist carrying a fatty-acid chain that binds albumin and stretches its half-life to about a week. It slows gastric emptying, increases glucose-dependent insulin secretion, and acts on hypothalamic appetite centres.
Semaglutide dosing schedule
The escalation below is the one used in the STEP phase 3 obesity programme and carried onto the approved weight-management label. It exists to limit gastrointestinal effects — the trials escalated slowly for tolerability, not because the lower steps do more.
| Phase | Amount | Frequency | Notes |
|---|---|---|---|
| Weeks 1–4 | 0.25 mg | Once weekly | Tolerability lead-in, not an intended effective amount. |
| Weeks 5–8 | 0.5 mg | Once weekly | First escalation. |
| Weeks 9–12 | 1.0 mg | Once weekly | |
| Weeks 13–16 | 1.7 mg | Once weekly | |
| Week 17 onward | 2.4 mg | Once weekly | Maintenance amount for the remainder of the trial. |
Study length: 68 weeks in STEP 1, with the maintenance amount reached at week 17.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Semaglutide: 10, 15, 20, 30, 50 mg.
Storage and stability
Reported effects
- Gastrointestinal effects — nausea, vomiting, diarrhoea, constipation — were the most frequently reported events in STEP 1 and are the reason for the slow escalation.
- Trial reporting notes gallbladder-related events more often than placebo.
- Labels in this drug class carry a boxed warning about thyroid C-cell tumours seen in rodents; human relevance is not established.
Sourcing Semaglutide
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
Semaglutide at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
