Retatrutide protocol
Retatrutide (GIP / GLP-1 / glucagon triple agonist). Dosing on this page comes from a published human trial or an approved product label, cited below.
How Retatrutide works
Adds glucagon-receptor agonism to the GIP/GLP-1 combination. Glucagon activity is thought to raise energy expenditure directly, which is the proposed reason for the larger phase 2 weight changes.
Retatrutide dosing schedule
From the phase 2 obesity trial. This compound is still investigational — there is no approved label, so the schedule below is a trial design rather than a marketed product.
| Phase | Amount | Frequency | Notes |
|---|---|---|---|
| Weeks 1–4 | 2 mg | Once weekly | Starting step for the higher arms. |
| Weeks 5–8 | 4 mg | Once weekly | Maintenance for the 4 mg arm. |
| Weeks 9–12 | 6 mg | Once weekly | Escalation step. |
| Weeks 13–16 | 8 mg | Once weekly | Maintenance for the 8 mg arm. |
| Weeks 17–20 | 10 mg | Once weekly | Escalation step. |
| Week 21 onward | 12 mg | Once weekly | Highest arm in the phase 2 trial. |
Study length: 48 weeks. Separate arms escalated to 1, 4, 8 and 12 mg maintenance.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Retatrutide: 10, 15, 20, 30, 50 mg.
Storage and stability
Reported effects
- Gastrointestinal effects were dose-related and concentrated in escalation.
- The trial reported dose-dependent heart-rate increases — the finding most specific to the glucagon component.
- No approved label exists and long-term safety is not established.
Sourcing Retatrutide
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
Retatrutide at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
