Protocol Reference
Animal data only
FOXO4-DRI protocol
FOXO4-DRI (FOXO4 D-retro-inverso senolytic peptide). The published work on this compound is animal or cell-culture research. No human dosing schedule exists to cite.
PepGuru Research Team·Reviewed Aug 2026
Category
Longevity & Cellular
Common vials
Not stocked by our featured supplier
Half-life
Not established in humans
Route in the literature
Not established
Evidence level
Animal data only
How FOXO4-DRI works
A D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 in senescent cells, pushing those cells into apoptosis while sparing healthy ones. It is the best-known designed senolytic peptide.
FOXO4-DRI dosing — what the literature actually supports
Animal data only. FOXO4-DRI comes from a single influential 2017 mouse study and follow-on preclinical work. There has never been a human trial. There is no human pharmacokinetic data, no safety data, and no schedule that can be cited. Selectively triggering apoptosis is also a mechanism where guessing an amount is a categorically bad idea.
We publish a schedule when there is a citable human source and we say so when there is not. Filling this space with a number nobody measured would make the page look more complete and be worth less than nothing to you.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for FOXO4-DRI: Not stocked by our featured supplier.
Open the FOXO4-DRI calculator → Unit converter
Storage and stability
Dry powder
Cold, dark and dry. Lyophilized peptide is the stable form — keep it that way until you intend to use it.
After reconstitution
Refrigerate at 2–8 °C, protect from light, and plan around a limited window. Do not freeze a reconstituted vial — freeze-thaw damages peptides.
Mixing
Run bacteriostatic water down the inside wall of the vial rather than onto the powder, then swirl. Never shake.
Inspect before use
A clear solution is expected. Cloudiness or particles mean discard, not use.
Full storage guide → · Cloudy solution?
Reported effects
- No human safety data of any kind.
- The mouse work reported restored fitness and hair density in aged animals, which is the finding that drove interest.
- Deliberately inducing cell death is not a mechanism with a forgiving margin for error.
Sourcing FOXO4-DRI
Our featured supplier does not stock this compound, and we are not going to point you at a vendor we have not looked at. Use the COA checklist on whoever you do buy from, and check the batch number on the certificate against the vial you receive.
COA checklist → How we vet suppliers
Sources and further reading
For laboratory research use only. This page documents what the published literature reports about FOXO4-DRI. It is not a recommendation, not a treatment plan, and not medical advice. Compounds referenced are sold strictly as research chemicals and are not for human or veterinary use. Some supplier links are affiliate links and may earn us a commission. This never affects tier placement or review conclusions.
