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Protocol Reference
Animal data only

MOTS-c protocol

MOTS-c (mitochondrial ORF of the 12S rRNA type-c). The published work on this compound is animal or cell-culture research. No human dosing schedule exists to cite.

PepGuru Research Team·Reviewed Aug 2026
Category
Longevity & Cellular
Common vials
10 mg
Half-life
Not established in humans
Route in the literature
Not established
Evidence level
Animal data only

How MOTS-c works

A 16-amino-acid peptide encoded in mitochondrial DNA rather than the nuclear genome — one of a small group of mitochondrial-derived peptides. Rodent work reports effects on AMPK signalling, insulin sensitivity and exercise capacity.

MOTS-c dosing — what the literature actually supports

Animal data only. MOTS-c is measured in human blood as an endogenous peptide, and those observational studies are sometimes misread as dosing evidence. They are not — measuring a peptide’s natural circulating level says nothing about what happens when you inject it. There is no human trial of administered MOTS-c and no schedule to cite. The animal work uses intraperitoneal amounts per kilogram of mouse.

We publish a schedule when there is a citable human source and we say so when there is not. Filling this space with a number nobody measured would make the page look more complete and be worth less than nothing to you.

Reconstitution and measurement

This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for MOTS-c: 10 mg.

Open the MOTS-c calculator → Unit converter

Storage and stability

Dry powder
Cold, dark and dry. Lyophilized peptide is the stable form — keep it that way until you intend to use it.
After reconstitution
Refrigerate at 2–8 °C, protect from light, and plan around a limited window. Do not freeze a reconstituted vial — freeze-thaw damages peptides.
Mixing
Run bacteriostatic water down the inside wall of the vial rather than onto the powder, then swirl. Never shake.
Inspect before use
A clear solution is expected. Cloudiness or particles mean discard, not use.

Full storage guide → · Cloudy solution?

Reported effects

  • No human administration safety data.
  • Rodent studies report improved insulin sensitivity and exercise capacity, particularly in aged or high-fat-diet models.

Sourcing MOTS-c

Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.

MOTS-c at Summit Research Supply → Grade a COA first

Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.

Sources and further reading

For laboratory research use only. This page documents what the published literature reports about MOTS-c. It is not a recommendation, not a treatment plan, and not medical advice. Compounds referenced are sold strictly as research chemicals and are not for human or veterinary use. Some supplier links are affiliate links and may earn us a commission. This never affects tier placement or review conclusions.
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