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Protocol Reference
Animal data only

Follistatin protocol

Follistatin (activin/myostatin-binding glycoprotein). The published work on this compound is animal or cell-culture research. No human dosing schedule exists to cite.

Category
Growth Hormone Axis
Common vials
1 mg
Half-life
Short for the native protein
Route in the literature
Not established
Evidence level
Animal data only

How Follistatin works

A glycoprotein that binds and neutralises members of the TGF-beta family including activin A and myostatin. Blocking myostatin removes a brake on muscle growth, which is the basis of the interest in it.

Follistatin dosing — what the literature actually supports

Animal data only. The human work in this area has used follistatin gene therapy — a viral vector delivering the FS-344 gene in small trials for muscular dystrophy — not injections of follistatin protein. Those trials establish nothing about an injected protein schedule, and the two approaches are not comparable. There is no human trial of injected follistatin protein to cite.

We publish a schedule when there is a citable human source and we say so when there is not. Filling this space with a number nobody measured would make the page look more complete and be worth less than nothing to you.

Reconstitution and measurement

This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Follistatin: 1 mg.

Open the Follistatin calculator → Unit converter

Storage and stability

Dry powder
Cold, dark and dry. Lyophilized peptide is the stable form — keep it that way until you intend to use it.
After reconstitution
Refrigerate at 2–8 °C, protect from light, and plan around a limited window. Do not freeze a reconstituted vial — freeze-thaw damages peptides.
Mixing
Run bacteriostatic water down the inside wall of the vial rather than onto the powder, then swirl. Never shake.
Inspect before use
A clear solution is expected. Cloudiness or particles mean discard, not use.

Full storage guide → · Cloudy solution?

Reported effects

  • No human safety data for injected follistatin protein.
  • Because follistatin binds activin as well as myostatin, its effects extend beyond muscle into reproductive and inflammatory signalling — a reason the safety question is not simply "more muscle".

Sourcing Follistatin

Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.

Follistatin at Summit Research Supply → Grade a COA first

Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.

For laboratory research use only. This page documents what the published literature reports about Follistatin. It is not a recommendation, not a treatment plan, and not medical advice. Compounds referenced are sold strictly as research chemicals and are not for human or veterinary use. Some supplier links are affiliate links and may earn us a commission. This never affects tier placement or review conclusions.
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